PROSTATECTOMY IN EXTREME OLD AGE.

Brain pathologies in extreme old age.

With an emphasis on evolving concepts in the field, we evaluated neuropathologic data from very old research volunteers whose brain autopsies were performed at the University of Kentucky Alzheimer's Disease Center, incorporating data from the Georgia Centenarian Study (n = 49 cases included), Nun Study (n = 17), and University of Kentucky Alzheimer's Disease Center (n = 11) cohorts. Average age...

RNA Editing Genes Associated with Extreme Old Age in Humans and with Lifespan in C. elegans

BACKGROUND The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered. METHODOLOGY/PRINCIPAL FINDINGS Here, we fi...

Obesity in old age.

Many older people in developed countries are overweight or obese. The prevalence is increasing as more people reach old age already overweight. Obesity in old age is associated with increased morbidity and a reduction in quality of life. The relative increase in mortality is less in older than young adults and the body weight associated with maximal survival increases with advancing age. Althou...

Spirometry in old age.

Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent in older people [1–4]. This well established fact has not, however, overcome the problem of underdiagnosis or misdiagnosis of both conditions in old age, with the inevitable effect on morbidity , and possibly mortality [1, 5]. Properly performed spirometric measurements of Forced Expiratory Volume in 1 second (FEV1) an...

Disability in Old Age